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The Evolutionary Dynamics of a Rapidly Mutating Virus within and between Hosts: The Case of Hepatitis C Virus Article Metrics Related Content Comments: 0 To add a note , highlight some text. Hide notes Make a general comment Jump to Abstract Author Summary Introduction Results Discussion Model Supporting Information Acknowledgments Author Contributions References Fabio Luciani 1 # * , Samuel Alizon 2 # * 1 Centre for Infection and Inflammation Research (CIIR), School of Medical Sciences, University of New South Wales, Sydney, Australia, 2 Institut für Integrative Biologie, ETH, Zürich, Switzerland Abstract Top Many pathogens associated with chronic infections evolve so rapidly that strains found late in an infection have little in common with the initial strain. This raises questions at different levels of analysis because rapid within-host evolution affects the course of an infection, but it can also affect the possibility for natural selection to act at the between-host level. We p...